I remember quite liking Hospital myself. Had an all star cast, most of which have probably never made anything for channel 5 since.
Well, there was a follow-up, the similarly-themed Hotel!, which then sat on the shelf for months and months.
I quite enjoyed it, you could certainly argue that like The Comic Strip on C4 it effectively set out the channel's stall on its first night. Everyone forgets comedy was a big part of the early C5 schedules and they stripped comedy shows every night at 11.40 for the first few months. Of those, The Comedy Store and Club Class were bog-standard stand-up shows (although the latter emphasised black stand-ups) and Tibs and Fibs was a bloody awful medical-themed panel show.
The two most interesting shows were Bring Me The Head of Light Entertainment and We Know Where You Live. The former was a panel show, produced by Anglia and indeed filmed in Norwich, which was devised by Lee Hurst but was basically I'm Sorry I Haven't A Clue on the telly. Hurst was one of the captains, alongside Fred Macaualey, and Graham Norton hosted, and it was an entertaining half hour, and lasted a couple of series, although by the end all three regulars had left, with the Canadian comedian Sean Cullen taking over as host.
And We Know Where You Live was a sketch show which is most famous now for its stellar cast, including Fiona Allen, Sanjeev Bhaskar, Amanda Holden and Simon Pegg, and they repeated it a few years later when they'd all become incredibly famous. It wasn't very good, though, filmed on a microscopic budget, but the producers went on to make a similar show for BBC2 called Bruiser which, like that show, had a cast which went on to become very famous - Olivia Colman, Martin Freeman, David Mitchell, Robert Webb - and, like that show, wasn't very good.
Anyway, when all those C5 comedy shows ended their runs after three months, that was it for the regular comedy slot and the following week Prisoner Cell Block H was there every night instead. Most of the shows came back but all over the schedule and there was never a regular comedy slot on C5 after that.